Of Money and Mummies

I recently visited the Metropolitan Museum of Art in New York City. There, you will find the Sackler Wing which contains treasures from the age of the Egyptian pharaohs. You will also find Arthur M. Sackler galleries at the Smithsonian Institute ,Harvard and Beijing University. Many people do not know the Sackler name apart from their association with these lofty cultural institutions.

Arthur M. Sackler has been referred to as a marketing genius and the godfather of the modern-day drug advertising industry.  He developed  drug marketing techniques such as: direct to consumer advertising , sponsoring luxurious all expense paid medical education courses for doctors, glamorizing drugs as a quick fixes, and  paying for "scientific" studies backing the need for and/or efficacy of the particular drug being studied.

Arthur Sackler, who was already rich, made a fortune marketing and selling Librium and Valium. Later, younger brothers Mortimer and Raymond  joined Arthur in acquiring a little known drug company called the Purdue Frederick Company. Arthur died in 1987 at the age of 73.  In 1996 the family owned company, now known as Purdue Pharma introduced it's new blockbuster drug, Oxycontin.

Oxycontin is a very powerful, long acting narcotic which is should only be prescribed for  serious pain. Purdue Pharma  recognized even before the drug was marketed that they would face stiff resistance from doctors who were concerned about the potential for  OxyContin to be abused by patients or cause addiction.

Taking a chapter from brother Arthur's drug marketing playbook, Mortimer and Raymond embarked on the most aggressive marketing campaign ever undertaken by a pharmaceutical company for a narcotic painkiller. Purdue Pharma marketed  OxyContin to doctors like general practitioners, who often had little training in the treatment of serious pain or in recognizing signs of drug abuse in patients. One of their techniques was to fly physicians in to conferences about the "inadequate treatment of pain" and the need for doctors to aggressively prescribe narcotics like Oxycontin to their patients.

Just a few years after the drug’s introduction in 1996, annual sales reached $1 billion.

 In reality, Oxycontin proved to be a powerfully addictive drug. Some users  including teenagers, soon discovered that chewing an OxyContin pill or crushing one and then snorting the powder or injecting it with a needle produced a high as powerful as heroin. By 2000, parts of the United States, particularly rural areas, began to see skyrocketing rates of addiction and crime related to use of the drug. The drug came to be known among certain circles as "hillbilly heroin"

 A  comprehensive review of the problem appeared in the journal Pain Physician http://www.painphysicianjournal.com/2006/october/2006;9;287-321.pdf

CDC and DEA data included in the review suggested that from 1997-2004 there was a:

> 556% increase in the sales of oxycodone;

> 500% increase in therapeutic grams of oxycodone used,

> 568% increase in the non-medical use of OxyContin (especially among young people)

 > 129% increase in opioid-related deaths [without heroin or cocaine]:

Using this data, the author extrapolated that the number of deaths from Oxycontin could surpass the deaths from 911 and the Iraq war combined!

 By 2007 the government caught up with Purdue which resulted in  three current and former executives pleaded guilty  to criminal charges that they misled regulators, doctors and patients about the drug’s risk of addiction and its potential to be abused. Purdue paid over $600 million in criminal and civil penalties.

Photographs by Don Petersen for The New York Times

From left, Howard R. Udell, the top lawyer for Purdue Pharma; Dr. Paul D. Goldenheim, the company’s former medical director; and Michael Friedman, Purdue’s president.

The last chapter of the Oxycontin saga has not been written. Despite their assertions to the contrary, Purdue Pharma has not cleaned up their act. Read between the lines on Partners Against Pain and you'll see some of Arthur's old tricks still being used.

There is much more to be written about Purdue Pharma and their dirty and deadly deeds. However, I was just so struck by seeing the Sackler name associated with such a venerable institution as the Metropolitan Museum of Art that I thought you should know what this family did to deserve having a wing of a famous art museum named after them.

Is Big Pharma's next blockbuster Viagra for the brain?

I was recently walking through La Guardia airport in a typical traveler's daze when a prominently displayed magazine cover jumped out at me.The title was "Pills to make you smarter".

I was hooked. I had to read more. Make no mistake. I wasn't in the market for a magazine in the first place. I was already heavily laden with the six issues of my local bar publication that I had been intending to read. And frankly, if I was going to buy a magazine it was pretty tempting to succumb to the urge to find out what exactly is going on with Lindsey Lohan. But the magazine marketing geniuses made a first time purchaser of Scientific American out of me.

The article, "Turbocharging the brain", queries: "Will a pill at breakfast improve concentration and memory-and will it do so without long term detriment to your health"? The article chronicles the fascinating scientific developments in cognitive enhancement drugs to treat Alzheimers and other dementias. But, it also raises a very disturbing question. Will these drugs ultimately be marketed and sold to healthy people as "lifestyle enhancement" drugs?

Currently, neuroethicists are debating this issue in the neuroscientific community. I certainly am not qualified to enter that debate. However, this is what I do know. With the advent of direct to consumer marketing, the big pharmaceutical companies have spoon fed us a steady diet of propoganda that there is a pill for everything that ails us. We are the "super size me" generation who believes that more is better. Multi-billion dollar industries have profited from our desire to eat more, be stronger, look better, and perform better in the bedroom.

The temptation to "super size" our brains could create an enormous demand for these "smart drugs", or as some have referred to them "viagra for the brain". As one neuro ethicist put it "Within the pharmaceutical field, people recognize that a successful cognitive enhancer could be the best selling pharmaceutical of all time".  We needn't say more at this point. With the potential for hundreds of billions of dollars to be made, the pharmaceutical industry will find a way to use their slick marketing machines to convince us that we "need" these drugs. They will pay scientists and physicians to write articles in esteemed medical journals advocating their use and minimizing any potential side effects. Mark my words. It may not be in my lifetime, but this will come to fruition.

So, at the end of the day, the pharmaceutical industry will continue to wield enormous power over us. Some futurists have concocted the symbol "H1" to denote an enhanced version of humanity. Think of all the "lifestyle enhancement " drugs that can be peddled to the super-sized human.  The question is what does this make us as human beings, what would a society of super-sized humans look like and would you want to live in it?